2NPA
the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Peroxisome proliferator-activated receptor alpha | polymer | 270 | 30513.6 | 2 | UniProt (Q07869) Pfam (PF00104) In PDB | Homo sapiens (human) | PPAR-alpha |
| 2 | B, D | SRC- peptide from Nuclear receptor coactivator 1 | polymer | 15 | 1848.2 | 2 | UniProt (Q2T9G5) UniProt (by SIFTS) (Q15788) In PDB | SRC- peptide from steroid receptor coactivator | |
| 3 | A, C | (2R,3E)-2-{4-[(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHOXY]BENZYL}-3-(PROPOXYIMINO)BUTANOIC ACID | non-polymer | 436.5 | 2 | Chemie (MMB) | |||
| 4 | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, C: 199 - 468 (UniProt: Q07869)
| PDB | External Database | Details |
|---|---|---|
| Ala 232 | Lys 232 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64723.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 873.0 | |
| All* | Total formula weight | 65596.5 |
