2NPA

the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MMB A 1201

Chain	Residue
A	ILE272
A	ILE354
A	MET355
A	HIS440
A	TYR464
A	HOH1203
A	PHE273
A	CYS275
A	CYS276
A	GLN277
A	SER280
A	TYR314
A	LEU321
A	VAL332

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MMB C 2201

Chain	Residue
C	PHE273
C	CYS276
C	SER280
C	TYR314
C	LEU321
C	VAL332
C	ILE354
C	HIS440
C	LEU460
C	TYR464
C	HOH2209

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	227
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	258
Details	Region: {"description":"Required for heterodimerization with RXRA"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19116277","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ET1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Essential for heterodimerization with RXRA"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

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