2NP8
Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
Summary for 2NP8
Entry DOI | 10.2210/pdb2np8/pdb |
Related | 1MQ4 |
Descriptor | Serine/threonine-protein kinase 6, SULFATE ION, N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | aurora a kinase, aik, aurora 2 kinase, kinase, kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 32045.67 |
Authors | Tari, L.W.,Hoffman, I.D.,Bensen, D.C.,Hunter, M.J.,Nix, J.,Nelson, K.J.,McRee, D.E.,Swanson, R.V. (deposition date: 2006-10-26, release date: 2006-12-26, Last modification date: 2023-08-30) |
Primary citation | Tari, L.W.,Hoffman, I.D.,Bensen, D.C.,Hunter, M.J.,Nix, J.,Nelson, K.J.,McRee, D.E.,Swanson, R.V. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors. Bioorg.Med.Chem.Lett., 17:688-691, 2007 Cited by PubMed: 17157005DOI: 10.1016/j.bmcl.2006.10.086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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