2NP8
Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase 6 | polymer | 272 | 31440.2 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Aurora-A, Breast-tumor-amplified kinase |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | A | N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE | non-polymer | 413.4 | 1 | Chemie (CC3) | |||
| 4 | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 120 | - | cloning artifact |
| Ala 121 | - | cloning artifact |
| Met 122 | - | cloning artifact |
| Gly 123 | - | cloning artifact |
| Ser 124 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31440.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 605.5 | |
| All* | Total formula weight | 32045.7 |
