2NN6

Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40

Summary for 2NN6

Entry DOI	10.2210/pdb2nn6/pdb
Descriptor	Polymyositis/scleroderma autoantigen 1, Exosome complex exonuclease RRP41, Exosome complex exonuclease RRP43, ... (9 entities in total)
Functional Keywords	rna, exosome, pm/scl, exoribonuclease, phosphorolytic, ribonuclease, hydrolase-transferase complex, hydrolase/transferase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q9NPD3 Q96B26 Q9NQT5 Q13868 Nucleus, nucleolus: Q9NQT4 Q15024 Q9Y3B2 Cytoplasm (Probable): Q5RKV6
Total number of polymer chains	9
Total formula weight	272665.69
Authors	Lima, C.D. (deposition date: 2006-10-23, release date: 2006-12-26, Last modification date: 2023-12-27)
Primary citation	Liu, Q.,Greimann, J.C.,Lima, C.D. Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell(Cambridge,Mass.), 127:1223-1237, 2006 Cited by PubMed: 17174896 DOI: 10.1016/j.cell.2006.10.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.35 Å)

Structure validation