2MUT

Solution structure of the F231L mutant ERCC1-XPF dimerization region

Summary for 2MUT

• Entry DOI: 10.2210/pdb2mut/pdb
• NMR Information: BMRB: 25232
• Descriptor: DNA excision repair protein ERCC-1, DNA repair endonuclease XPF (2 entities in total)
• Functional Keywords: ercc1-xpf, f231l, nucleotide excision repair, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 3: Nucleus. Isoform 4: Nucleus: P07992; Nucleus : Q92889
• Total number of polymer chains: 2
• Total formula weight: 20216.19

Authors

Faridounnia, M.,Wienk, H.,Kovacic, L.,Folkers, G.E.,Jaspers, N.G.J.,Kaptein, R.,Hoeijmakers, J.H.J.,Boelens, R. (deposition date: 2014-09-17, release date: 2015-06-24, Last modification date: 2023-06-14)

• Primary citation: Faridounnia, M.,Wienk, H.,Kovacic, L.,Folkers, G.E.,Jaspers, N.G.,Kaptein, R.,Hoeijmakers, J.H.,Boelens, R.; The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex.; J.Biol.Chem., 290:20541-20555, 2015; PubMed: 26085086; DOI: 10.1074/jbc.M114.635169

Experimental method

SOLUTION NMR