2MUT
Solution structure of the F231L mutant ERCC1-XPF dimerization region
Summary for 2MUT
Entry DOI | 10.2210/pdb2mut/pdb |
NMR Information | BMRB: 25232 |
Descriptor | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF (2 entities in total) |
Functional Keywords | ercc1-xpf, f231l, nucleotide excision repair, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 3: Nucleus. Isoform 4: Nucleus: P07992 Nucleus : Q92889 |
Total number of polymer chains | 2 |
Total formula weight | 20216.19 |
Authors | Faridounnia, M.,Wienk, H.,Kovacic, L.,Folkers, G.E.,Jaspers, N.G.J.,Kaptein, R.,Hoeijmakers, J.H.J.,Boelens, R. (deposition date: 2014-09-17, release date: 2015-06-24, Last modification date: 2024-05-15) |
Primary citation | Faridounnia, M.,Wienk, H.,Kovacic, L.,Folkers, G.E.,Jaspers, N.G.,Kaptein, R.,Hoeijmakers, J.H.,Boelens, R. The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex. J.Biol.Chem., 290:20541-20555, 2015 Cited by PubMed: 26085086DOI: 10.1074/jbc.M114.635169 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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