2M50

Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).

Summary for 2M50

• Entry DOI: 10.2210/pdb2m50/pdb
• Related: 2M4X 2M4Z
• NMR Information: BMRB: 19032
• Descriptor: Mu-theraphotoxin-Hh2a (1 entity in total)
• Functional Keywords: venom toxin, toxin
• Biological source: Haplopelma schmidti (Chinese bird spider,Chinese golden earth tiger)
• Cellular location: Secreted: P83303
• Total number of polymer chains: 1
• Total formula weight: 4062.76

Authors

Gibbs, A.,Minassian, N.,Flinspach, M.,Wickenden, A. (deposition date: 2013-02-12, release date: 2013-06-19, Last modification date: 2023-11-29)

• Primary citation: Minassian, N.A.,Gibbs, A.,Shih, A.Y.,Liu, Y.,Neff, R.A.,Sutton, S.W.,Mirzadegan, T.,Connor, J.,Fellows, R.,Husovsky, M.,Nelson, S.,Hunter, M.J.,Flinspach, M.,Wickenden, A.D.; Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a).; J.Biol.Chem., 288:22707-22720, 2013; PubMed: 23760503; DOI: 10.1074/jbc.M113.461392

Experimental method

SOLUTION NMR