2KM3
Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats
Summary for 2KM3
| Entry DOI | 10.2210/pdb2km3/pdb |
| Related | 143D 1K8P 2AQY 2GKU 2JSK 2JSL 2JSM 2JSQ 2KF7 2KF8 |
| Descriptor | DNA (5'-D(*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*G)-3') (1 entity in total) |
| Functional Keywords | anticancer targets, ctaggg repeat, g-quadruplex, human telomere instability, dna |
| Total number of polymer chains | 1 |
| Total formula weight | 6938.46 |
| Authors | Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T. (deposition date: 2009-07-17, release date: 2009-11-03, Last modification date: 2024-05-01) |
| Primary citation | Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T. Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad Nucleic Acids Res., 37:6239-6248, 2009 Cited by PubMed Abstract: Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA. PubMed: 19692585DOI: 10.1093/nar/gkp630 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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