2KM3

Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats

2KM3 の概要

• エントリーDOI: 10.2210/pdb2km3/pdb
• 関連するPDBエントリー: 143D 1K8P 2AQY 2GKU 2JSK 2JSL 2JSM 2JSQ 2KF7 2KF8
• 分子名称: DNA (5'-D(*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*G)-3') (1 entity in total)
• 機能のキーワード: anticancer targets, ctaggg repeat, g-quadruplex, human telomere instability, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6938.46

構造登録者

Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T. (登録日: 2009-07-17, 公開日: 2009-11-03, 最終更新日: 2024-05-01)

主引用文献

Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T.
Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad
Nucleic Acids Res., 37:6239-6248, 2009

PubMed Abstract: Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.

PubMed: 19692585
DOI: 10.1093/nar/gkp630

実験手法

SOLUTION NMR