2K9E

NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide

Summary for 2K9E

• Entry DOI: 10.2210/pdb2k9e/pdb
• NMR Information: BMRB: 15983
• Descriptor: Kappa-stichotoxin-She3a (1 entity in total)
• Functional Keywords: protein, ionic channel inhibitor, nematocyst, neurotoxin, potassium channel inhibitor, secreted, toxin
• Biological source: Stichodactyla helianthus
• Total number of polymer chains: 1
• Total formula weight: 4422.17

Authors

Galea, C.A. (deposition date: 2008-10-09, release date: 2009-01-20, Last modification date: 2023-11-15)

• Primary citation: Pennington, M.W.,Beeton, C.,Galea, C.A.,Smith, B.J.,Chi, V.,Monaghan, K.P.,Garcia, A.,Rangaraju, S.,Giuffrida, A.,Plank, D.,Crossley, G.,Nugent, D.,Khaytin, I.,Lefievre, Y.,Peshenko, I.,Dixon, C.,Chauhan, S.,Orzel, A.,Inoue, T.,Hu, X.,Moore, R.V.,Norton, R.S.,Chandy, K.G.; Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes; Mol.Pharmacol., 75:762-773, 2009; PubMed: 19122005; DOI: 10.1124/mol.108.052704

Experimental method

SOLUTION NMR