2K9E

NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0042151	cellular_component	nematocyst

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Key residue for binding both Kv1.2/KCNA2 and Kv1.3/KCNA3 (occludes the channel pore like a cork in a bottle)","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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