2K9E
NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042151 | cellular_component | nematocyst |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for binding both Kv1.2/KCNA2 and Kv1.3/KCNA3 (occludes the channel pore like a cork in a bottle)","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
