2JZW

How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription

Summary for 2JZW

DescriptorHIV-1 nucleocapsid protein NCp7(12-55), DNA (5'-D(*DGP*DTP*DCP*DCP*DCP*DTP*DGP*DTP*DTP*DCP*DGP*DGP*DGP*DC)-3'), ZINC ION (3 entities in total)
Functional Keywordshuman immunodeficiency virus type 1 (hiv-1), nuclear magnetic resonance (nmr), nucleocapsid protein (ncp7), primer binding site (pbs), exchange, viral protein-dna complex, viral protein/dna
Total number of polymer chains2
Total molecular weight9417.39
Authors
Bourbigot, S.,Ramalanjaona, N.,Salgado, G.F.J.,Mely, Y.,Roques, B.P.,Bouaziz, S.,Morellet, N. (deposition date: 2008-01-21, release date: 2009-01-13, Last modification date: 2011-07-13)
Primary citation
Bourbigot, S.,Ramalanjaona, N.,Boudier, C.,Salgado, G.F.,Roques, B.P.,Mely, Y.,Bouaziz, S.,Morellet, N.
How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription.
J.Mol.Biol., 383:1112-1128, 2008
PubMed: 18773912 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2008.08.046
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers21.2%9.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

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