2JZW

How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription

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Functional Information from GO Data

ChainGOidnamespacecontents
A0042025cellular_componenthost cell nucleus
A0020002cellular_componenthost cell plasma membrane
A0072494cellular_componenthost multivesicular body
A0019013cellular_componentviral nucleocapsid
A0055036cellular_componentvirion membrane
A0004190molecular_functionaspartic-type endopeptidase activity
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0004533molecular_functionexoribonuclease H activity
A0008289molecular_functionlipid binding
A0003723molecular_functionRNA binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0005198molecular_functionstructural molecule activity
A0008270molecular_functionzinc ion binding
A0015074biological_processDNA integration
A0006310biological_processDNA recombination
A0075713biological_processestablishment of integrated proviral latency
A0039651biological_processinduction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
A0039657biological_processsuppression by virus of host gene expression
A0046718biological_processviral entry into host cell
A0044826biological_processviral genome integration into host DNA
A0075732biological_processviral penetration into host nucleus
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC13BINDING SITE FOR RESIDUE ZN A 56
ChainResidue
ACYS15
ACYS18
AHIS23

AC25BINDING SITE FOR RESIDUE ZN A 57
ChainResidue
ACYS36
ACYS39
ALYS41
AHIS44
AGLN45

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ZN_2jzw_A_5613ZINC ION binding site
ChainResidueligand
ACYS15-LYS20ZN: ZINC ION
AHIS23-ALA25ZN: ZINC ION
ACYS28ZN: ZINC ION
AALA30ZN: ZINC ION
AARG29ZN: ZINC ION
AASN27ZN: ZINC ION

ZN_2jzw_A_5714ZINC ION binding site
ChainResidueligand
ACYS36ZN: ZINC ION
ALYS38-LYS41ZN: ZINC ION
AHIS44-MET46ZN: ZINC ION
ACYS49ZN: ZINC ION
AGLU51ZN: ZINC ION
AGLN53ZN: ZINC ION
ATHR50ZN: ZINC ION
AARG52ZN: ZINC ION
AASP48ZN: ZINC ION

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0002212EGF-like domain signature 1. C-x-C-x(2)-{V}-x(2)-G-{C}-x-C
ChainResidueDetails
BDC103-DC114

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails