2JK7

XIAP BIR3 bound to a Smac Mimetic

2JK7 の概要

• エントリーDOI: 10.2210/pdb2jk7/pdb
• 関連するPDBエントリー: 1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2VSL
• 分子名称: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, (3S,6S,7Z,10AS)-N-(DIPHENYLMETHYL)-6-{[(2S)-2-(METHYLIDENEAMINO)BUTANOYL]AMINO}-5-OXO-1,2,3,5,6,9,10,10A-OCTAHYDROPYRROLO[1,2-A]AZOCINE-3-CARBOXAMIDE, ZINC ION, ... (4 entities in total)
• 機能のキーワード: zinc-finger, polymorphism, smac mimetic, metal-binding, bir3, zinc, ligase, apoptosis, cytoplasm, x-linked inhibitor of apoptosis, ubl conjugation pathway, thiol protease inhibitor, phosphoprotein, ubl conjugation, protease inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P98170
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13845.77

構造登録者

Saito, N.G.,Meagher, J.L.,Stuckey, J.A. (登録日: 2008-08-21, 公開日: 2008-11-04, 最終更新日: 2024-05-01)

• 主引用文献: Sun, H.,Stuckey, J.A.,Nikolovska-Coleska, Z.,Qin, D.,Meagher, J.L.,Qiu, S.,Lu, J.,Yang, C.,Saito, N.G.,Wang, S.; Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (Xiap).; J.Med.Chem., 51:7169-, 2008; PubMed: 18954041; DOI: 10.1021/JM8006849

実験手法

X-RAY DIFFRACTION (2.82 Å)