2JBP

Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)

Summary for 2JBP

• Entry DOI: 10.2210/pdb2jbp/pdb
• Related: 1KWP 1NXK 1NY3 2JBO
• Descriptor: MAP KINASE-ACTIVATED PROTEIN KINASE 2, 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE (3 entities in total)
• Functional Keywords: ser-thr kinase, mapkap kinase 2, phosphorylation, small molecule inhibitor, mk2, kinase, atp site, transferase, atp- binding, serine/threonine-protein kinase, co-crystallization, nucleotide-binding
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 12
• Total formula weight: 455729.69

Authors

Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U. (deposition date: 2006-12-09, release date: 2007-03-20, Last modification date: 2023-12-13)

• Primary citation: Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U.; Structural basis for a high affinity inhibitor bound to protein kinase MK2.; J. Mol. Biol., 369:735-745, 2007; PubMed: 17449059; DOI: 10.1016/j.jmb.2007.03.004

Experimental method

X-RAY DIFFRACTION (3.31 Å)