2J8S

Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors

Summary for 2J8S

Entry DOI	10.2210/pdb2j8s/pdb
Related	1IWG 1OY6 1OY8 1OY9 1OYD 1OYE 1T9T 1T9U 1T9V 1T9W 1T9X 1T9Y 2GIF 2HRT
Descriptor	ACRIFLAVINE RESISTANCE PROTEIN B, DARPIN, DODECYL-BETA-D-MALTOSIDE, ... (5 entities in total)
Functional Keywords	membrane protein-complex, designed ankyrin repeat protein, multidrug resistance protein, co-crystallization, antibiotic resistance, inner membrane, protein complex, membrane protein, rnd, membrane, inhibitor, transport, transmembrane, drug-efflux pump, transport protein, antibiotic resistance-inhibitor complex
Biological source	ESCHERICHIA COLI More
Total number of polymer chains	5
Total formula weight	385733.97
Authors	Sennhauser, G.,Amstutz, P.,Briand, C.,Storchenegger, O.,Gruetter, M.G. (deposition date: 2006-10-27, release date: 2007-01-23, Last modification date: 2023-12-13)
Primary citation	Sennhauser, G.,Amstutz, P.,Briand, C.,Storchenegger, O.,Grutter, M.G. Drug Export Pathway of Multidrug Exporter Acrb Revealed by Darpin Inhibitors. Plos Biol., 5:E7-, 2007 Cited by PubMed: 17194213 DOI: 10.1371/JOURNAL.PBIO.0050007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54 Å)

Structure validation