2J8S
Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0009636 | biological_process | response to toxic substance |
A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
A | 0015562 | molecular_function | efflux transmembrane transporter activity |
A | 0015567 | molecular_function | alkane transmembrane transporter activity |
A | 0015721 | biological_process | bile acid and bile salt transport |
A | 0015895 | biological_process | alkane transport |
A | 0015908 | biological_process | fatty acid transport |
A | 0016020 | cellular_component | membrane |
A | 0022857 | molecular_function | transmembrane transporter activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0042908 | biological_process | xenobiotic transport |
A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
A | 0042930 | biological_process | enterobactin transport |
A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
A | 0046677 | biological_process | response to antibiotic |
A | 0055085 | biological_process | transmembrane transport |
A | 0098567 | cellular_component | periplasmic side of plasma membrane |
A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
A | 1990281 | cellular_component | efflux pump complex |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0009636 | biological_process | response to toxic substance |
B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
B | 0015562 | molecular_function | efflux transmembrane transporter activity |
B | 0015567 | molecular_function | alkane transmembrane transporter activity |
B | 0015721 | biological_process | bile acid and bile salt transport |
B | 0015895 | biological_process | alkane transport |
B | 0015908 | biological_process | fatty acid transport |
B | 0016020 | cellular_component | membrane |
B | 0022857 | molecular_function | transmembrane transporter activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0042908 | biological_process | xenobiotic transport |
B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
B | 0042930 | biological_process | enterobactin transport |
B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
B | 0046677 | biological_process | response to antibiotic |
B | 0055085 | biological_process | transmembrane transport |
B | 0098567 | cellular_component | periplasmic side of plasma membrane |
B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
B | 1990281 | cellular_component | efflux pump complex |
C | 0005515 | molecular_function | protein binding |
C | 0005886 | cellular_component | plasma membrane |
C | 0009410 | biological_process | response to xenobiotic stimulus |
C | 0009636 | biological_process | response to toxic substance |
C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
C | 0015562 | molecular_function | efflux transmembrane transporter activity |
C | 0015567 | molecular_function | alkane transmembrane transporter activity |
C | 0015721 | biological_process | bile acid and bile salt transport |
C | 0015895 | biological_process | alkane transport |
C | 0015908 | biological_process | fatty acid transport |
C | 0016020 | cellular_component | membrane |
C | 0022857 | molecular_function | transmembrane transporter activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0042908 | biological_process | xenobiotic transport |
C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
C | 0042930 | biological_process | enterobactin transport |
C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
C | 0046677 | biological_process | response to antibiotic |
C | 0055085 | biological_process | transmembrane transport |
C | 0098567 | cellular_component | periplasmic side of plasma membrane |
C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE LMT A 3046 |
Chain | Residue |
A | ILE27 |
A | LEU28 |
A | LYS29 |
A | VAL32 |
A | VAL341 |
A | LEU377 |
A | LMU3049 |
B | LMT3037 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE LMT A 3047 |
Chain | Residue |
A | GLY444 |
A | MET447 |
A | VAL448 |
A | ALA451 |
A | VAL883 |
A | VAL884 |
A | CYS887 |
A | ALA890 |
A | LEU891 |
C | ARG8 |
A | GLY440 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE LMT A 3048 |
Chain | Residue |
A | LEU449 |
A | VAL452 |
A | PHE453 |
A | TYR467 |
A | PHE556 |
A | SER561 |
A | PHE563 |
A | GLY870 |
A | ASN871 |
A | GLN872 |
A | TYR877 |
A | ASN923 |
A | LEU932 |
A | ILE935 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE LMU A 3049 |
Chain | Residue |
A | ILE335 |
A | HIS338 |
A | VAL341 |
A | LYS342 |
A | LEU344 |
A | VAL345 |
A | ILE348 |
A | ASP633 |
A | TRP634 |
A | ALA635 |
A | LMT3046 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE LMT B 3035 |
Chain | Residue |
B | TYR527 |
B | SER530 |
B | GLY533 |
B | ARG536 |
B | ARG540 |
B | TYR541 |
D | ASP72 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE LMT B 3036 |
Chain | Residue |
A | ARG8 |
A | PHE11 |
A | ILE18 |
A | ILE19 |
B | GLY440 |
B | VAL443 |
B | GLY444 |
B | CYS887 |
B | ALA890 |
B | LEU891 |
site_id | AC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE LMT B 3037 |
Chain | Residue |
A | ILE18 |
A | LEU21 |
A | LEU25 |
A | LYS29 |
A | LMT3046 |
B | GLN872 |
B | SER875 |
B | LEU876 |
B | ILE879 |
B | VAL883 |
B | LEU886 |
B | CYS887 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE LMT C 3042 |
Chain | Residue |
C | GLU339 |
C | ILE991 |
C | SER992 |
C | THR993 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE LMT C 3043 |
Chain | Residue |
C | SER530 |
C | ILE534 |
C | ARG536 |
C | SER537 |
C | ARG540 |
C | TYR541 |
C | LEU544 |
C | ILE547 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE LMT C 3044 |
Chain | Residue |
B | LYS29 |
C | PHE458 |
C | ASN871 |
C | SER875 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE LMT C 3046 |
Chain | Residue |
C | GLY97 |
C | ALA457 |
C | PHE458 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 462 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996 |
Chain | Residue | Details |
A | MET1-PRO9 | |
B | GLU414-ILE438 | |
B | ALA491-THR538 | |
B | ALA889-PRO898 | |
B | LEU944-LEU972 | |
B | ILE1019-HIS1049 | |
C | MET1-PRO9 | |
C | LEU357-THR365 | |
C | GLU414-ILE438 | |
C | ALA491-THR538 | |
C | ALA889-PRO898 | |
A | LEU357-THR365 | |
C | LEU944-LEU972 | |
C | ILE1019-HIS1049 | |
A | GLU414-ILE438 | |
A | ALA491-THR538 | |
A | ALA889-PRO898 | |
A | LEU944-LEU972 | |
A | ILE1019-HIS1049 | |
B | MET1-PRO9 | |
B | LEU357-THR365 |
site_id | SWS_FT_FI2 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=1 |
Chain | Residue | Details |
A | ILE10-LEU28 | |
B | ILE10-LEU28 | |
C | ILE10-LEU28 |
site_id | SWS_FT_FI3 |
Number of Residues | 1932 |
Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:15919996 |
Chain | Residue | Details |
A | LYS29-SER336 | |
B | PHE556-ASN871 | |
B | ARG919-ASP924 | |
B | THR993-GLY998 | |
C | LYS29-SER336 | |
C | PHE386-ASN391 | |
C | PHE458-ALA465 | |
C | PHE556-ASN871 | |
C | ARG919-ASP924 | |
C | THR993-GLY998 | |
A | PHE386-ASN391 | |
A | PHE458-ALA465 | |
A | PHE556-ASN871 | |
A | ARG919-ASP924 | |
A | THR993-GLY998 | |
B | LYS29-SER336 | |
B | PHE386-ASN391 | |
B | PHE458-ALA465 |
site_id | SWS_FT_FI4 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=2 |
Chain | Residue | Details |
A | ILE337-TYR356 | |
B | ILE337-TYR356 | |
C | ILE337-TYR356 |
site_id | SWS_FT_FI5 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=3 |
Chain | Residue | Details |
A | LEU366-ALA385 | |
B | LEU366-ALA385 | |
C | LEU366-ALA385 |
site_id | SWS_FT_FI6 |
Number of Residues | 63 |
Details | TRANSMEM: Helical; Name=4 |
Chain | Residue | Details |
A | THR392-VAL413 | |
B | THR392-VAL413 | |
C | THR392-VAL413 |
site_id | SWS_FT_FI7 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=5 |
Chain | Residue | Details |
A | GLN439-ALA457 | |
B | GLN439-ALA457 | |
C | GLN439-ALA457 |
site_id | SWS_FT_FI8 |
Number of Residues | 72 |
Details | TRANSMEM: Helical; Name=6 |
Chain | Residue | Details |
A | ILE466-PRO490 | |
B | ILE466-PRO490 | |
C | ILE466-PRO490 |
site_id | SWS_FT_FI9 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=7 |
Chain | Residue | Details |
A | GLY539-LEU555 | |
B | GLY539-LEU555 | |
C | GLY539-LEU555 |
site_id | SWS_FT_FI10 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=8 |
Chain | Residue | Details |
A | GLN872-LEU888 | |
B | GLN872-LEU888 | |
C | GLN872-LEU888 |
site_id | SWS_FT_FI11 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=9 |
Chain | Residue | Details |
A | PHE899-PHE918 | |
B | PHE899-PHE918 | |
C | PHE899-PHE918 |
site_id | SWS_FT_FI12 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=10 |
Chain | Residue | Details |
A | VAL925-ILE943 | |
B | VAL925-ILE943 | |
C | VAL925-ILE943 |
site_id | SWS_FT_FI13 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=11 |
Chain | Residue | Details |
A | ARG973-SER992 | |
B | ARG973-SER992 | |
C | ARG973-SER992 |
site_id | SWS_FT_FI14 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=12 |
Chain | Residue | Details |
A | ALA999-ALA1018 | |
B | ALA999-ALA1018 | |
C | ALA999-ALA1018 |