2J8S

Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors

2J8S の概要

• エントリーDOI: 10.2210/pdb2j8s/pdb
• 関連するPDBエントリー: 1IWG 1OY6 1OY8 1OY9 1OYD 1OYE 1T9T 1T9U 1T9V 1T9W 1T9X 1T9Y 2GIF 2HRT
• 分子名称: ACRIFLAVINE RESISTANCE PROTEIN B, DARPIN, DODECYL-BETA-D-MALTOSIDE, ... (5 entities in total)
• 機能のキーワード: membrane protein-complex, designed ankyrin repeat protein, multidrug resistance protein, co-crystallization, antibiotic resistance, inner membrane, protein complex, membrane protein, rnd, membrane, inhibitor, transport, transmembrane, drug-efflux pump, transport protein, antibiotic resistance-inhibitor complex
• 由来する生物種: ESCHERICHIA COLI; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 385733.97

構造登録者

Sennhauser, G.,Amstutz, P.,Briand, C.,Storchenegger, O.,Gruetter, M.G. (登録日: 2006-10-27, 公開日: 2007-01-23, 最終更新日: 2023-12-13)

• 主引用文献: Sennhauser, G.,Amstutz, P.,Briand, C.,Storchenegger, O.,Grutter, M.G.; Drug Export Pathway of Multidrug Exporter Acrb Revealed by Darpin Inhibitors.; Plos Biol., 5:E7-, 2007; PubMed: 17194213; DOI: 10.1371/JOURNAL.PBIO.0050007

実験手法

X-RAY DIFFRACTION (2.54 Å)