2J6W

R164N mutant of the RUNX1 Runt domain

Summary for 2J6W

• Entry DOI: 10.2210/pdb2j6w/pdb
• Related: 1EAN 1EAO 1EAQ 1HJB 1HJC 1IO4
• Descriptor: RUNT-RELATED TRANSCRIPTION FACTOR 1, CHLORIDE ION (3 entities in total)
• Functional Keywords: transcription factor, transcription/dna, chloride binding, acute myeloid leukemia, transcription regulation, transcription, nuclear protein, phosphorylation, aml, runx1, ig fold, runt domain, dna-binding
• Biological source: MUS MUSCULUS (MOUSE)
• Cellular location: Nucleus: Q03347
• Total number of polymer chains: 2
• Total formula weight: 31102.73

Authors

Grembecka, J.,Zhe, L.,Lukasik, S.M.,Liu, Y.,Bielnicka, I.,Bushweller, J.H.,Speck, N.A. (deposition date: 2006-10-04, release date: 2007-10-09, Last modification date: 2023-12-13)

• Primary citation: Li, Z.,Lukasik, S.M.,Liu, Y.,Grembecka, J.,Bielnicka, I.,Bushweller, J.H.,Speck, N.A.; A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation.; J.Mol.Biol., 364:1073-, 2006; PubMed: 17059830; DOI: 10.1016/J.JMB.2006.10.002

Experimental method

X-RAY DIFFRACTION (2.6 Å)