2IUI

Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide

Summary for 2IUI

Entry DOI	10.2210/pdb2iui/pdb
Related	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH
Descriptor	Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta (3 entities in total)
Functional Keywords	transferase, phosphorylation, p85, sh2, pi3k, sh2 domain, sh3 domain, pi3-kinase, disease mutation
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P09619
Total number of polymer chains	4
Total formula weight	30664.25
Authors	Nolte, R.T.,Eck, M.J.,Schlessinger, J.,Shoelson, S.E.,Harrison, S.C. (deposition date: 2006-06-03, release date: 2006-06-06, Last modification date: 2021-04-28)
Primary citation	Nolte, R.T.,Eck, M.J.,Schlessinger, J.,Shoelson, S.E.,Harrison, S.C. Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3:364-, 1996 Cited by PubMed: 8599763 DOI: 10.1038/NSB0496-364 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation