2IUI

Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Phosphatidylinositol 3-kinase regulatory subunit alpha	polymer	120	13939.6	2	UniProt (P27986) Pfam (PF00017)	Homo sapiens (Human)	PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha
2	C, D (C, D)	Platelet-derived growth factor receptor beta	polymer	11	1392.6	2	UniProt (P09619)	Homo sapiens	PDGFR-beta,Beta platelet-derived growth factor receptor,Beta-type platelet-derived growth factor receptor,CD140 antigen-like family member B,Platelet-derived growth factor receptor 1,PDGFR-1
3	E, F, G, H (A, B, C, D)	water	water		18.0	117	Chemie (HOH)

Sequence modifications

A, B: 0 - 119 (UniProt: P27986)

PDB	External Database	Details
Asn 9	Asp 330	conflict

C, D: 201 - 211 (UniProt: P09619)

PDB	External Database	Details
Ile 202	Val 749	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	30664.2
All*	Total formula weight	30664.2

*Water molecules are not included.