2IUI
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 120 | 13939.6 | 2 | UniProt (P27986) Pfam (PF00017) In PDB | Homo sapiens (Human) | PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
2 | C, D | Platelet-derived growth factor receptor beta | polymer | 11 | 1392.6 | 2 | UniProt (P09619) In PDB | Homo sapiens | PDGFR-beta,Beta platelet-derived growth factor receptor,Beta-type platelet-derived growth factor receptor,CD140 antigen-like family member B,Platelet-derived growth factor receptor 1,PDGFR-1 |
3 | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 119 (UniProt: P27986)
C, D: 201 - 211 (UniProt: P09619)
PDB | External Database | Details |
---|---|---|
Asn 9 | Asp 330 | conflict |
PDB | External Database | Details |
---|---|---|
Ile 202 | Val 749 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 30664.2 | |
All* | Total formula weight | 30664.2 |