2ILT
Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor
Summary for 2ILT
Entry DOI | 10.2210/pdb2ilt/pdb |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NICKEL (II) ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | hsd1, nadp, inhibitor, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845 |
Total number of polymer chains | 1 |
Total formula weight | 31722.86 |
Authors | Longenecker, K.L.,Sorensen, B.,Judge, R.,Qin, W.,Link, J.T. (deposition date: 2006-10-03, release date: 2007-04-03, Last modification date: 2024-02-21) |
Primary citation | Sorensen, B.,Winn, M.,Rohde, J.,Shuai, Q.,Wang, J.,Fung, S.,Monzon, K.,Chiou, W.,Stolarik, D.,Imade, H.,Pan, L.,Deng, X.,Chovan, L.,Longenecker, K.,Judge, R.,Qin, W.,Brune, M.,Camp, H.,Frevert, E.U.,Jacobson, P.,Link, J.T. Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors. Bioorg.Med.Chem.Lett., 17:527-532, 2007 Cited by PubMed: 17070044DOI: 10.1016/j.bmcl.2006.10.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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