2ILT

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor

Summary for 2ILT

Entry DOI	10.2210/pdb2ilt/pdb
Descriptor	Corticosteroid 11-beta-dehydrogenase isozyme 1, NICKEL (II) ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	hsd1, nadp, inhibitor, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
Total number of polymer chains	1
Total formula weight	31722.86
Authors	Longenecker, K.L.,Sorensen, B.,Judge, R.,Qin, W.,Link, J.T. (deposition date: 2006-10-03, release date: 2007-04-03, Last modification date: 2024-02-21)
Primary citation	Sorensen, B.,Winn, M.,Rohde, J.,Shuai, Q.,Wang, J.,Fung, S.,Monzon, K.,Chiou, W.,Stolarik, D.,Imade, H.,Pan, L.,Deng, X.,Chovan, L.,Longenecker, K.,Judge, R.,Qin, W.,Brune, M.,Camp, H.,Frevert, E.U.,Jacobson, P.,Link, J.T. Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors. Bioorg.Med.Chem.Lett., 17:527-532, 2007 Cited by PubMed: 17070044 DOI: 10.1016/j.bmcl.2006.10.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation