2ILT
Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | polymer | 275 | 30418.1 | 1 | UniProt (P28845) Pfam (PF00106) In PDB | Homo sapiens (human) | 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1 |
| 2 | A | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
| 3 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 4 | A | 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE | non-polymer | 444.0 | 1 | Chemie (NN1) | |||
| 5 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A: 24 - 285 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Gln 11 | - | cloning artifact |
| His 12 | - | cloning artifact |
| Gln 13 | - | cloning artifact |
| His 14 | - | cloning artifact |
| Gln 15 | - | cloning artifact |
| His 16 | - | cloning artifact |
| Gln 17 | - | cloning artifact |
| His 18 | - | cloning artifact |
| Gln 19 | - | cloning artifact |
| His 20 | - | cloning artifact |
| Gln 21 | - | cloning artifact |
| Gln 22 | - | cloning artifact |
| Pro 23 | - | cloning artifact |
| Ser 272 | Cys 271 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30418.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1304.8 | |
| All* | Total formula weight | 31722.9 |
