2ILT

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005496	molecular_function	steroid binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006706	biological_process	steroid catabolic process
A	0006713	biological_process	glucocorticoid catabolic process
A	0008202	biological_process	steroid metabolic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0042803	molecular_function	protein homodimerization activity
A	0047022	molecular_function	7-beta-hydroxysteroid dehydrogenase (NADP+) activity
A	0050661	molecular_function	NADP binding
A	0070524	molecular_function	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
A	0102196	molecular_function	cortisol dehydrogenase (NADP+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 801

Chain	Residue
A	HIS18
A	HIS18
A	HIS18
A	HIS20
A	HIS20
A	HIS20

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 802

Chain	Residue
A	HIS14
A	HIS14
A	HIS14
A	HIS12
A	HIS12
A	HIS12

---

site_id	AC3
Number of Residues	32
Details	BINDING SITE FOR RESIDUE NAP A 901

Chain	Residue
A	GLY41
A	ALA42
A	SER43
A	LYS44
A	GLY45
A	ILE46
A	ALA65
A	ARG66
A	SER67
A	GLY91
A	THR92
A	MET93
A	ASN119
A	HIS120
A	ILE121
A	VAL168
A	SER169
A	TYR183
A	LYS187
A	LEU215
A	GLY216
A	LEU217
A	ILE218
A	THR220
A	THR222
A	ALA223
A	NN1902
A	HOH925
A	HOH935
A	HOH947
A	HOH960
A	HOH997

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NN1 A 902

Chain	Residue
A	ILE121
A	THR124
A	SER170
A	PRO178
A	TYR183
A	GLY216
A	LEU217
A	THR222
A	ALA223
A	ALA226
A	NAP901
A	HOH1010

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlagkvaypmVaaYSASKFALdGFFsSIR

Chain	Residue	Details
A	SER170-ARG198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	37
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15513927","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17919905","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18069989","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18485702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18553955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19217779","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15513927","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XU9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS187
A	SER170
A	TYR183

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS187
A	SER170
A	TYR183
A	ASN143

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS187
A	VAL180

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS187
A	TYR183

---