2IKI

Human aldose reductase complexed with halogenated IDD-type inhibitor

Summary for 2IKI

Entry DOI	10.2210/pdb2iki/pdb
Related	1US0 2IKG 2IKH 2IKJ
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, ... (4 entities in total)
Functional Keywords	tim barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37058.37
Authors	Steuber, H.,Koch, C.,Heine, A.,Klebe, G. (deposition date: 2006-10-02, release date: 2007-05-01, Last modification date: 2023-10-25)
Primary citation	Steuber, H.,Heine, A.,Klebe, G. Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution J.Mol.Biol., 368:618-638, 2007 Cited by PubMed: 17368668 DOI: 10.1016/j.jmb.2006.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation