2IKI
Human aldose reductase complexed with halogenated IDD-type inhibitor
Summary for 2IKI
Entry DOI | 10.2210/pdb2iki/pdb |
Related | 1US0 2IKG 2IKH 2IKJ |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37058.37 |
Authors | Steuber, H.,Koch, C.,Heine, A.,Klebe, G. (deposition date: 2006-10-02, release date: 2007-05-01, Last modification date: 2023-10-25) |
Primary citation | Steuber, H.,Heine, A.,Klebe, G. Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution J.Mol.Biol., 368:618-638, 2007 Cited by PubMed: 17368668DOI: 10.1016/j.jmb.2006.12.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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