2IKJ

Human aldose reductase complexed with nitro-substituted IDD-type inhibitor

Summary for 2IKJ

Entry DOI	10.2210/pdb2ikj/pdb
Related	1US0 2IKG 2IKH 2IKI
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID, ... (4 entities in total)
Functional Keywords	tim barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37006.48
Authors	Steuber, H.,Koch, C.,Heine, A.,Klebe, G. (deposition date: 2006-10-02, release date: 2007-05-01, Last modification date: 2023-10-25)
Primary citation	Steuber, H.,Heine, A.,Klebe, G. Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution J.Mol.Biol., 368:618-638, 2007 Cited by PubMed: 17368668 DOI: 10.1016/j.jmb.2006.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation