2II5

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Isobutyryl-Coenzyme A-bound form

Summary for 2II5

• Entry DOI: 10.2210/pdb2ii5/pdb
• Related: 2IHW 2II3 2II4
• Descriptor: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, ACETATE ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: cubic core, homo trimer, isobutyryl-coa-bound form, transferase
• Biological source: Bos taurus (cattle)
• Cellular location: Mitochondrion matrix : P11181
• Total number of polymer chains: 8
• Total formula weight: 237883.74

Authors

Kato, M.,Wynn, R.M.,Chuang, J.L.,Brautigam, C.A.,Custorio, M.,Chuang, D.T. (deposition date: 2006-09-27, release date: 2006-12-26, Last modification date: 2024-02-21)

• Primary citation: Kato, M.,Wynn, R.M.,Chuang, J.L.,Brautigam, C.A.,Custorio, M.,Chuang, D.T.; A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex.; Embo J., 25:5983-5994, 2006; PubMed: 17124494; DOI: 10.1038/sj.emboj.7601444

Experimental method

X-RAY DIFFRACTION (2.5 Å)