2II4

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Coenzyme A-bound form

Summary for 2II4

Entry DOI	10.2210/pdb2ii4/pdb
Related	2IHW 2II3 2II5
Descriptor	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, CHLORIDE ION, COENZYME A, ... (4 entities in total)
Functional Keywords	cubic core, homo trimer, coa-bound form, transferase
Biological source	Bos taurus (cattle)
Cellular location	Mitochondrion matrix : P11181
Total number of polymer chains	8
Total formula weight	236378.32
Authors	Kato, M.,Wynn, R.M.,Chuang, J.L.,Brautigam, C.A.,Custorio, M.,Chuang, D.T. (deposition date: 2006-09-27, release date: 2006-12-26, Last modification date: 2024-02-21)
Primary citation	Kato, M.,Wynn, R.M.,Chuang, J.L.,Brautigam, C.A.,Custorio, M.,Chuang, D.T. A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex. Embo J., 25:5983-5994, 2006 Cited by PubMed: 17124494 DOI: 10.1038/sj.emboj.7601444 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation