Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2II4

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Coenzyme A-bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016746	molecular_function	acyltransferase activity
B	0016746	molecular_function	acyltransferase activity
C	0016746	molecular_function	acyltransferase activity
D	0016746	molecular_function	acyltransferase activity
E	0016746	molecular_function	acyltransferase activity
F	0016746	molecular_function	acyltransferase activity
G	0016746	molecular_function	acyltransferase activity
H	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 801

Chain	Residue
C	HOH834

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 802

Chain	Residue
A	LYS349
B	HOH820

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 803

Chain	Residue
A	HOH827
C	LYS349

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 804

Chain	Residue
D	HOH827
F	LYS349

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 805

Chain	Residue
D	LYS349
E	HOH827

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 806

Chain	Residue
E	LYS349
E	HOH834
F	HOH829

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 807

Chain	Residue
A	ARG370
B	ARG370
C	ARG370

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 808

Chain	Residue
D	ARG370
E	ARG370
F	ARG370

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 809

Chain	Residue
H	LYS349
H	HOH840

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 810

Chain	Residue
G	ARG370
G	ARG370
G	ARG370

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL G 811

Chain	Residue
G	LYS349

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 812

Chain	Residue
H	ARG370
H	ARG370
H	ARG370

site_id	BC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE COA A 500

Chain	Residue
A	ARG230
A	SER245
A	PHE246
A	MET247
A	ALA286
A	MET287
A	ASP288
A	LEU313
A	GLN317
A	SER338
A	ASN339
A	GLY341
A	SER342
A	GLY363
A	THR364
A	ILE365
A	HOH820
A	HOH824
A	HOH831
A	HOH832
A	HOH839
B	HIS391
B	GLY396

site_id	BC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE COA B 500

Chain	Residue
B	ARG230
B	SER245
B	PHE246
B	MET247
B	ALA286
B	MET287
B	ASP288
B	LEU293
B	GLN317
B	SER338
B	ASN339
B	GLY341
B	SER342
B	GLY363
B	THR364
B	ILE365
B	HOH815
B	HOH823
B	HOH826
C	HIS391
C	GLY396

site_id	BC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE COA C 500

Chain	Residue
A	HIS391
A	GLY396
A	HOH819
C	ARG230
C	SER245
C	PHE246
C	MET247
C	ALA286
C	MET287
C	ASP288
C	LEU313
C	GLN317
C	SER338
C	ASN339
C	GLY341
C	SER342
C	GLY363
C	THR364
C	ILE365
C	HOH825
C	HOH829
C	HOH844

site_id	BC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE COA D 500

Chain	Residue
D	ASP288
D	LEU313
D	GLN317
D	SER338
D	ASN339
D	GLY341
D	SER342
D	GLY363
D	THR364
D	ILE365
D	HOH813
D	HOH836
D	HOH839
E	HIS391
E	GLY396
D	ARG230
D	SER245
D	PHE246
D	MET247
D	ALA286
D	MET287

site_id	BC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE COA E 500

Chain	Residue
E	ARG230
E	LYS234
E	SER245
E	PHE246
E	MET247
E	ALA286
E	MET287
E	ASP288
E	LEU293
E	LEU313
E	GLN317
E	SER338
E	ASN339
E	GLY341
E	SER342
E	GLY363
E	THR364
E	ILE365
E	HOH813
E	HOH825
F	HIS391
F	GLY396

site_id	BC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE COA F 500

Chain	Residue
D	HIS391
D	GLY396
F	ARG230
F	LYS234
F	SER245
F	PHE246
F	MET247
F	ALA286
F	MET287
F	ASP288
F	LEU313
F	GLN317
F	SER338
F	ASN339
F	GLY341
F	SER342
F	GLY363
F	THR364
F	ILE365
F	HOH822
F	HOH823
F	HOH825

site_id	CC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE COA G 500

Chain	Residue
G	ARG230
G	LYS234
G	SER245
G	PHE246
G	MET247
G	ILE285
G	ALA286
G	MET287
G	ASP288
G	GLN317
G	SER338
G	ASN339
G	GLY341
G	SER342
G	GLY363
G	THR364
G	ILE365
G	GLY396
G	HOH818
G	HOH827
G	HOH829

site_id	CC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE COA H 500

Chain	Residue
H	ARG230
H	LYS243
H	SER245
H	PHE246
H	MET247
H	ILE285
H	ALA286
H	MET287
H	ASP288
H	GLN317
H	SER338
H	ASN339
H	GLY341
H	SER342
H	GLY363
H	THR364
H	ILE365
H	HIS391
H	GLY396
H	HOH821
H	HOH835
H	HOH838

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	HIS391
E	ASP395
F	HIS391
F	ASP395
G	HIS391
G	ASP395
H	HIS391
H	ASP395
A	ASP395
B	HIS391
B	ASP395
C	HIS391
C	ASP395
D	HIS391
D	ASP395
E	HIS391

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000269\|PubMed:17124494, ECO:0007744\|PDB:2II4

Chain	Residue	Details
A	ARG230
B	ARG230
B	SER245
B	ASP288
B	GLN317
B	SER338
B	ASN339
B	SER342
B	GLY363
B	ILE365
C	ARG230
A	SER245
C	SER245
C	ASP288
C	GLN317
C	SER338
C	ASN339
C	SER342
C	GLY363
C	ILE365
D	ARG230
D	SER245
A	ASP288
D	ASP288
D	GLN317
D	SER338
D	ASN339
D	SER342
D	GLY363
D	ILE365
E	ARG230
E	SER245
E	ASP288
A	GLN317
E	GLN317
E	SER338
E	ASN339
E	SER342
E	GLY363
E	ILE365
F	ARG230
F	SER245
F	ASP288
F	GLN317
A	SER338
F	SER338
F	ASN339
F	SER342
F	GLY363
F	ILE365
G	ARG230
G	SER245
G	ASP288
G	GLN317
G	SER338
A	ASN339
G	ASN339
G	SER342
G	GLY363
G	ILE365
H	ARG230
H	SER245
H	ASP288
H	GLN317
H	SER338
H	ASN339
A	SER342
H	SER342
H	GLY363
H	ILE365
A	GLY363
A	ILE365

site_id	SWS_FT_FI3
Number of Residues	32
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P53395

Chain	Residue	Details
A	LYS182
C	LYS189
C	LYS243
C	LYS374
D	LYS182
D	LYS189
D	LYS243
D	LYS374
E	LYS182
E	LYS189
E	LYS243
A	LYS189
E	LYS374
F	LYS182
F	LYS189
F	LYS243
F	LYS374
G	LYS182
G	LYS189
G	LYS243
G	LYS374
H	LYS182
A	LYS243
H	LYS189
H	LYS243
H	LYS374
A	LYS374
B	LYS182
B	LYS189
B	LYS243
B	LYS374
C	LYS182

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P53395

Chain	Residue	Details
A	LYS200
B	LYS200
C	LYS200
D	LYS200
E	LYS200
F	LYS200
G	LYS200
H	LYS200

site_id	SWS_FT_FI5
Number of Residues	16
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P53395

Chain	Residue	Details
A	LYS228
E	LYS379
F	LYS228
F	LYS379
G	LYS228
G	LYS379
H	LYS228
H	LYS379
A	LYS379
B	LYS228
B	LYS379
C	LYS228
C	LYS379
D	LYS228
D	LYS379
E	LYS228

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P11182

Chain	Residue	Details
A	LYS234
B	LYS234
C	LYS234
D	LYS234
E	LYS234
F	LYS234
G	LYS234
H	LYS234

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)