2I4J

Crystal structure of the complex between PPARgamma and the agonist LT160 (ureidofibrate derivative)

Summary for 2I4J

Related1PRG 2PRG 4PRG 2I4Z
DescriptorPeroxisome proliferator-activated receptor gamma, (2R)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID (3 entities in total)
Functional Keywordsbundle of alpha-helices and a small four-stranded beta-sheet, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight65513.89
Authors
Pochetti, G.,Mazza, F. (deposition date: 2006-08-22, release date: 2007-04-17, Last modification date: 2017-10-18)
Primary citation
Pochetti, G.,Godio, C.,Mitro, N.,Caruso, D.,Galmozzi, A.,Scurati, S.,Loiodice, F.,Fracchiolla, G.,Tortorella, P.,Laghezza, A.,Lavecchia, A.,Novellino, E.,Mazza, F.,Crestani, M.
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands
J.Biol.Chem., 282:17314-17324, 2007
PubMed: 17403688 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M702316200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.278253.2%5.6%12.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report