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2I4J

Crystal structure of the complex between PPARgamma and the agonist LT160 (ureidofibrate derivative)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE DRJ A 999
ChainResidue
APHE226
AMET329
AVAL339
ALEU340
AILE341
AHIS449
ALEU453
ALEU465
ALEU469
ATYR473
AHOH1104
ACYS285
AGLN286
AARG288
ASER289
AALA292
AILE296
AHIS323
AILE326

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

229380

PDB entries from 2024-12-25

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