2I0E
Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor
Summary for 2I0E
| Entry DOI | 10.2210/pdb2i0e/pdb |
| Descriptor | Protein Kinase C-beta II, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-2-METHYL-1H-INDOL-3-YL}-4-(2-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE (3 entities in total) |
| Functional Keywords | protein kinase c beta ii, protein kinase c, serine/threonine protein kinase, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm (By similarity): P05771 |
| Total number of polymer chains | 2 |
| Total formula weight | 82473.79 |
| Authors | Grodsky, N.B.,Love, R.L. (deposition date: 2006-08-10, release date: 2006-11-14, Last modification date: 2024-04-03) |
| Primary citation | Grodsky, N.,Li, Y.,Bouzida, D.,Love, R.,Jensen, J.,Nodes, B.,Nonomiya, J.,Grant, S. Structure of the Catalytic Domain of Human Protein Kinase C beta II Complexed with a Bisindolylmaleimide Inhibitor Biochemistry, 45:13970-13981, 2006 Cited by PubMed: 17115692DOI: 10.1021/bi061128h PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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