2I0E

Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Protein Kinase C-beta II	polymer	353	40796.4	2	UniProt (P05771) Pfam (PF00069) Pfam (PF00433) In PDB	Homo sapiens (human)
2	A, B	3-{1-[3-(DIMETHYLAMINO)PROPYL]-2-METHYL-1H-INDOL-3-YL}-4-(2-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE	non-polymer		440.5	2	Chemie (PDS)
3		water	water		18.0	115	Chemie (HOH)

Sequence modifications

A, B: 321 - 670 (UniProt: P05771)

PDB	External Database	Details
Tpo 500	Thr 499	modified residue
-	Arg 621	SEE REMARK 999
Cys 622	Asp 622	SEE REMARK 999
Gly 623	Lys 623	SEE REMARK 999
Asn 625	Asp 625	SEE REMARK 999
Ala 626	Thr 626	SEE REMARK 999
Glu 627	Ser 627	SEE REMARK 999
Arg 631	Lys 631	SEE REMARK 999
Phe 632	Glu 632	SEE REMARK 999
His 636	Gln 636	SEE REMARK 999
Pro 638	Val 638	SEE REMARK 999
Val 639	Glu 639	SEE REMARK 999
Tpo 641	Thr 641	modified residue
Pro 643	Thr 643	SEE REMARK 999
Gln 645	Lys 645	SEE REMARK 999
Glu 646	Leu 646	SEE REMARK 999
Val 647	Phe 647	SEE REMARK 999
Arg 649	Met 649	SEE REMARK 999
Ile 651	Leu 651	SEE REMARK 999
Ser 654	Asn 654	SEE REMARK 999
Glu 657	Ala 657	SEE REMARK 999
Sep 660	Ser 660	modified residue
Phe 661	Tyr 661	SEE REMARK 999
Val 662	Thr 662	SEE REMARK 999
Ser 664	Pro 664	SEE REMARK 999
Leu 667	Val 667	SEE REMARK 999
Lys 668	Ile 668	SEE REMARK 999
Pro 669	Asn 669	SEE REMARK 999
Glu 670	Val 670	SEE REMARK 999
Val 671	-	SEE REMARK 999
Lys 672	-	SEE REMARK 999
Ser 673	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	81592.7
Non-Polymers*	Number of molecules	2
	Total formula weight	881.1
All*	Total formula weight	82473.8

*Water molecules are not included.