2HVR

Structure of T4 RNA Ligase 2 with Nicked 5'-Adenylated nucleic acid duplex containing a 3'-deoxyribonucleotide at the nick

Summary for 2HVR

• Entry DOI: 10.2210/pdb2hvr/pdb
• Related: 2HVQ 2HVS
• Descriptor: 5'-D(*AP*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*TP*TP*G)-3', 5'-D(*CP*AP*AP*TP*TP*GP*CP*GP*AP*C)-R(P*(OMC)P*C)-3', 5'-R(P*A)-D(P*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*T)-3', ... (6 entities in total)
• Functional Keywords: rna, ligase, lysine adenylate, t4, protein dna-rna complex, ligase-rna-dna complex, ligase/rna/dna
• Biological source: Enterobacteria phage T4
• Total number of polymer chains: 8
• Total formula weight: 106163.67

Authors

Nandakumar, J.,Lima, C.D. (deposition date: 2006-07-30, release date: 2006-10-17, Last modification date: 2023-08-30)

• Primary citation: Nandakumar, J.,Shuman, S.,Lima, C.D.; RNA Ligase Structures Reveal the Basis for RNA Specificity and Conformational Changes that Drive Ligation Forward.; Cell(Cambridge,Mass.), 127:71-84, 2006; PubMed: 17018278; DOI: 10.1016/j.cell.2006.08.038

Experimental method

X-RAY DIFFRACTION (2.45 Å)