2HVR
Structure of T4 RNA Ligase 2 with Nicked 5'-Adenylated nucleic acid duplex containing a 3'-deoxyribonucleotide at the nick
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003972 | molecular_function | RNA ligase (ATP) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0042245 | biological_process | RNA repair |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003972 | molecular_function | RNA ligase (ATP) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016874 | molecular_function | ligase activity |
| B | 0042245 | biological_process | RNA repair |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BTB C 201 |
| Chain | Residue |
| C | DT11 |
| C | DG12 |
| C | DG13 |
| C | DG14 |
| C | HOH128 |
| D | DC134 |
| D | OMC135 |
| D | O2C136 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BTB F 202 |
| Chain | Residue |
| F | DG13 |
| F | DG14 |
| G | DC134 |
| G | OMC135 |
| G | O2C136 |
| F | DG12 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BTB A 335 |
| Chain | Residue |
| A | ASN193 |
| A | GLU195 |
| A | LYS197 |
| B | VAL130 |
| B | THR131 |
| B | TRP215 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: N6-AMP-lysine intermediate => ECO:0000255|HAMAP-Rule:MF_04150, ECO:0000269|PubMed:17018278 |
| Chain | Residue | Details |
| A | LYS35 | |
| B | LYS35 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04150, ECO:0000269|PubMed:14962393, ECO:0000269|PubMed:17018278 |
| Chain | Residue | Details |
| A | GLU34 | |
| B | GLU99 | |
| B | LYS225 | |
| B | LYS227 | |
| A | ILE36 | |
| A | ASN40 | |
| A | GLU99 | |
| A | LYS225 | |
| A | LYS227 | |
| B | GLU34 | |
| B | ILE36 | |
| B | ASN40 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14962393, ECO:0000269|PubMed:17018278 |
| Chain | Residue | Details |
| A | LYS35 | |
| B | LYS35 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04150, ECO:0000269|PubMed:14962393 |
| Chain | Residue | Details |
| A | ARG55 | |
| B | ARG55 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04150, ECO:0000269|PubMed:17018278 |
| Chain | Residue | Details |
| A | ILE162 | |
| B | TYR206 | |
| A | LEU164 | |
| A | ASN166 | |
| A | GLU204 | |
| A | TYR206 | |
| B | ILE162 | |
| B | LEU164 | |
| B | ASN166 | |
| B | GLU204 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Interaction with RNA => ECO:0000255|HAMAP-Rule:MF_04150 |
| Chain | Residue | Details |
| A | ASN218 | |
| A | LYS314 | |
| B | ASN218 | |
| B | LYS314 |
