2HP4

Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor

Summary for 2HP4

• Entry DOI: 10.2210/pdb2hp4/pdb
• Descriptor: T-cell surface glycoprotein CD8 alpha chain, SULFATE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: cd8, co-receptor, soluble protein, kd, protein engineering, immunotherapy, immune-suppressor, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P01732
• Total number of polymer chains: 2
• Total formula weight: 26537.72

Authors

Rizkallah, P.J.,Cole, D.K.,Jakobsen, B.K.,Boulter, J.M.,Glick, M.,Gao, G.F. (deposition date: 2006-07-17, release date: 2007-02-06, Last modification date: 2023-10-25)

• Primary citation: Cole, D.K.,Rizkallah, P.J.,Boulter, J.M.,Sami, M.,Vuidepot, A.-L.,Glick, M.,Gao, F.,Bell, J.I.,Jakobsen, B.K.,Gao, G.F.; Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor; Proteins, 67:65-74, 2007; PubMed: 17243170; DOI: 10.1002/prot.21176

Experimental method

X-RAY DIFFRACTION (2.1 Å)