2HP4
Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor
Summary for 2HP4
Entry DOI | 10.2210/pdb2hp4/pdb |
Descriptor | T-cell surface glycoprotein CD8 alpha chain, SULFATE ION, GLYCEROL, ... (4 entities in total) |
Functional Keywords | cd8, co-receptor, soluble protein, kd, protein engineering, immunotherapy, immune-suppressor, immune system |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P01732 |
Total number of polymer chains | 2 |
Total formula weight | 26537.72 |
Authors | Rizkallah, P.J.,Cole, D.K.,Jakobsen, B.K.,Boulter, J.M.,Glick, M.,Gao, G.F. (deposition date: 2006-07-17, release date: 2007-02-06, Last modification date: 2023-10-25) |
Primary citation | Cole, D.K.,Rizkallah, P.J.,Boulter, J.M.,Sami, M.,Vuidepot, A.-L.,Glick, M.,Gao, F.,Bell, J.I.,Jakobsen, B.K.,Gao, G.F. Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor Proteins, 67:65-74, 2007 Cited by PubMed: 17243170DOI: 10.1002/prot.21176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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