2HLE

Structural and biophysical characterization of the EPHB4-EPHRINB2 protein protein interaction and receptor specificity.

Summary for 2HLE

Entry DOI	10.2210/pdb2hle/pdb
Related	1KGY 1NUK 2BBA
Descriptor	Ephrin type-B receptor 4, Ephrin-B2 (3 entities in total)
Functional Keywords	protein-protein interaction, receptor tryosine kinase, bi-directional cell signaling, transferase-transferase receptor complex, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, transferase/transferase receptor
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P54760 P52799
Total number of polymer chains	2
Total formula weight	37141.29
Authors	Chrencik, J.E.,Brooun, A.,Kuhn, P.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) (deposition date: 2006-07-06, release date: 2006-08-22, Last modification date: 2023-08-30)
Primary citation	Chrencik, J.E.,Brooun, A.,Kraus, M.L.,Recht, M.I.,Kolatkar, A.R.,Han, G.W.,Seifert, J.M.,Widmer, H.,Auer, M.,Kuhn, P. Structural and Biophysical Characterization of the EphB4-EphrinB2 Protein-Protein Interaction and Receptor Specificity. J.Biol.Chem., 281:28185-28192, 2006 Cited by PubMed: 16867992 DOI: 10.1074/jbc.M605766200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation