2HLE

Structural and biophysical characterization of the EPHB4-EPHRINB2 protein protein interaction and receptor specificity.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ephrin type-B receptor 4	polymer	188	21354.2	1	UniProt (P54760) Pfam (PF01404)	Homo sapiens (human)	Tyrosine-protein kinase receptor HTK, EPHB4
2	B (B)	Ephrin-B2	polymer	138	15787.1	1	UniProt (P52799) Pfam (PF00812)	Homo sapiens (human)	EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L, EPHRINB2
3	C, D (A, B)	water	water		18.0	79	Chemie (HOH)

Sequence modifications

A: 17 - 196 (UniProt: P54760)

PDB	External Database	Details
Ala 9	-	cloning artifact
Gly 10	-	cloning artifact
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag

B: 31 - 168 (UniProt: P52799)

PDB	External Database	Details
Arg 106	Lys 103	conflict
Val 111	Ile 108	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37141.3
All*	Total formula weight	37141.3

*Water molecules are not included.