2HI4

Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone

Summary for 2HI4

Entry DOI	10.2210/pdb2hi4/pdb
Related	1PQ2 1R90 1TQN 1Z10
Descriptor	Cytochrome P450 1A2, PROTOPORPHYRIN IX CONTAINING FE, 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, ... (4 entities in total)
Functional Keywords	cyp1a2, p450 1a2, p450, monooxygenase, drug metabolizing enzyme, alpha-naphthoflavone, benzo(h)flavone, 7, 8-benzoflavone, oxidoreductase, heme
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P05177
Total number of polymer chains	1
Total formula weight	57182.37
Authors	Sansen, S.,Yano, J.K.,Reynald, R.L.,Schoch, G.S.,Stout, C.D.,Johnson, E.F. (deposition date: 2006-06-29, release date: 2007-02-20, Last modification date: 2023-08-30)
Primary citation	Sansen, S.,Yano, J.K.,Reynald, R.L.,Schoch, G.A.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. J.Biol.Chem., 282:14348-14355, 2007 Cited by PubMed: 17311915 DOI: 10.1074/jbc.M611692200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation