2HI4

Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone

2HI4 の概要

• エントリーDOI: 10.2210/pdb2hi4/pdb
• 関連するPDBエントリー: 1PQ2 1R90 1TQN 1Z10
• 分子名称: Cytochrome P450 1A2, PROTOPORPHYRIN IX CONTAINING FE, 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, ... (4 entities in total)
• 機能のキーワード: cyp1a2, p450 1a2, p450, monooxygenase, drug metabolizing enzyme, alpha-naphthoflavone, benzo(h)flavone, 7, 8-benzoflavone, oxidoreductase, heme
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P05177
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57182.37

構造登録者

Sansen, S.,Yano, J.K.,Reynald, R.L.,Schoch, G.S.,Stout, C.D.,Johnson, E.F. (登録日: 2006-06-29, 公開日: 2007-02-20, 最終更新日: 2023-08-30)

• 主引用文献: Sansen, S.,Yano, J.K.,Reynald, R.L.,Schoch, G.A.,Griffin, K.J.,Stout, C.D.,Johnson, E.F.; Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.; J.Biol.Chem., 282:14348-14355, 2007; PubMed: 17311915; DOI: 10.1074/jbc.M611692200

実験手法

X-RAY DIFFRACTION (1.95 Å)