2HFK

Pikromycin thioesterase in complex with product 10-deoxymethynolide

Summary for 2HFK

• Entry DOI: 10.2210/pdb2hfk/pdb
• Related: 1MNA 2HFJ
• Descriptor: Type I polyketide synthase PikAIV, SULFATE ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: alpha/beta hydrolase, thioesterase, hydrolase
• Biological source: Streptomyces venezuelae
• Total number of polymer chains: 2
• Total formula weight: 68761.44

Authors

Akey, D.L.,Kittendorf, J.D.,Giraldes, J.W.,Fecik, R.A.,Sherman, D.H.,Smith, J.L. (deposition date: 2006-06-24, release date: 2006-09-19, Last modification date: 2023-08-30)

• Primary citation: Akey, D.L.,Kittendorf, J.D.,Giraldes, J.W.,Fecik, R.A.,Sherman, D.H.,Smith, J.L.; Structural Basis for Macrolactonization by the Pikromycin Thioesterase; NAT.CHEM.BIOL., 2:537-542, 2006; PubMed: 16969372; DOI: 10.1038/nchembio824

Experimental method

X-RAY DIFFRACTION (1.79 Å)