2HFK
Pikromycin thioesterase in complex with product 10-deoxymethynolide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 701 |
| Chain | Residue |
| A | ALA37 |
| A | GLN41 |
| A | ARG215 |
| A | HOH943 |
| A | HOH944 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 702 |
| Chain | Residue |
| B | HOH964 |
| B | HOH968 |
| B | HOH974 |
| B | HOH975 |
| A | ARG24 |
| B | ALA37 |
| B | GLN41 |
| B | ARG215 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 703 |
| Chain | Residue |
| A | ARG248 |
| B | GLN245 |
| B | GLU246 |
| B | GLU247 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 710 |
| Chain | Residue |
| A | HIS254 |
| A | HIS254 |
| A | ASP256 |
| A | ASP256 |
| A | HOH824 |
| A | HOH824 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS B 706 |
| Chain | Residue |
| B | ARG227 |
| B | TRP255 |
| B | ASP256 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 707 |
| Chain | Residue |
| A | ASP243 |
| B | ARG191 |
| B | GLN192 |
| B | HOH1108 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS B 708 |
| Chain | Residue |
| B | GLY76 |
| B | THR77 |
| B | ALA78 |
| B | ALA148 |
| B | GLY149 |
| B | GLY150 |
| B | E4H802 |
| B | HOH831 |
| B | HOH930 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS A 709 |
| Chain | Residue |
| A | GLY76 |
| A | THR77 |
| A | HIS147 |
| A | ALA148 |
| A | GLY149 |
| A | GLY150 |
| A | E4H801 |
| A | HOH811 |
| A | HOH885 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE E4H A 801 |
| Chain | Residue |
| A | TYR25 |
| A | GLY26 |
| A | LEU29 |
| A | THR77 |
| A | GLY149 |
| A | GLN183 |
| A | ILE186 |
| A | SER190 |
| A | ALA217 |
| A | DMS709 |
| A | HOH813 |
| A | HOH1013 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE E4H B 802 |
| Chain | Residue |
| B | TYR25 |
| B | THR77 |
| B | GLY149 |
| B | ILE186 |
| B | GLU187 |
| B | LEU193 |
| B | ALA217 |
| B | LEU220 |
| B | DMS708 |
| B | HOH931 |
| B | HOH933 |
| B | HOH936 |
| B | HOH1009 |
| B | HOH1012 |
| B | HOH1013 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for thioesterase activity","evidences":[{"source":"UniProtKB","id":"Q03133","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"16969372","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16969373","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; for thioesterase activity","evidences":[{"source":"UniProtKB","id":"Q03133","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"16969372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16969373","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16969372","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16969372","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16969373","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q03133","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
