2HDX

Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide

Summary for 2HDX

Entry DOI	10.2210/pdb2hdx/pdb
Descriptor	SH2-B PH domain containing signaling mediator 1 gamma isoform, Jak2 protein (3 entities in total)
Functional Keywords	sh2, jak2, phosphotyrosine, adapter protein, signaling protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	12
Total formula weight	81991.82
Authors	Hu, J.,Hubbard, S.R. (deposition date: 2006-06-21, release date: 2006-08-08, Last modification date: 2023-11-15)
Primary citation	Hu, J.,Hubbard, S.R. Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361:69-79, 2006 Cited by PubMed: 16824542 DOI: 10.1016/j.jmb.2006.05.070 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation