2HCT
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities
Summary for 2HCT
Entry DOI | 10.2210/pdb2hct/pdb |
Descriptor | ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE (3 entities in total) |
Functional Keywords | beta sheets, alpha bundle, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type II membrane protein: P28907 |
Total number of polymer chains | 2 |
Total formula weight | 61287.11 |
Authors | Liu, Q.,Kriksunov, I.A.,Hao, Q.,Graeff, R.,Lee, H.C. (deposition date: 2006-06-18, release date: 2006-08-22, Last modification date: 2023-08-30) |
Primary citation | Graeff, R.,Liu, Q.,Kriksunov, I.A.,Hao, Q.,Lee, H.C. Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities. J.Biol.Chem., 281:28951-28957, 2006 Cited by PubMed: 16861223DOI: 10.1074/jbc.M604370200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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