2HAP
STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION
Summary for 2HAP
Entry DOI | 10.2210/pdb2hap/pdb |
Descriptor | DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3'), PROTEIN (HEME ACTIVATOR PROTEIN), ... (5 entities in total) |
Functional Keywords | complex transcription factor-dna, asymmetry, transcriptional activation, hyperactive mutant, gene regulation-dna complex, gene regulation/dna |
Biological source | Saccharomyces cerevisiae (baker's yeast) More |
Total number of polymer chains | 4 |
Total formula weight | 31985.07 |
Authors | King, D.A.,Zhang, L.,Guarente, L.,Marmorstein, R. (deposition date: 1998-09-17, release date: 1999-11-10, Last modification date: 2024-02-14) |
Primary citation | King, D.A.,Zhang, L.,Guarente, L.,Marmorstein, R. Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation. Nat.Struct.Biol., 6:22-27, 1999 Cited by PubMed: 9886287DOI: 10.1038/4893 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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