2GU8
Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies
Summary for 2GU8
Entry DOI | 10.2210/pdb2gu8/pdb |
Descriptor | CAMP-dependent protein kinase, alpha-catalytic subunit, inhibitor of CAMP-dependent protein kinase, N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | camp-dependent protein kinase, pka, akt, kinase, drug design, ternary complex, signaling protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): P17612 |
Total number of polymer chains | 2 |
Total formula weight | 42076.76 |
Authors | Murray, J.M. (deposition date: 2006-04-28, release date: 2007-05-01, Last modification date: 2011-07-13) |
Primary citation | Lin, X.,Murray, J.M.,Rico, A.C.,Wang, M.X.,Chu, D.T.,Zhou, Y.,Del Rosario, M.,Kaufman, S.,Ma, S.,Fang, E.,Crawford, K.,Jefferson, A.B. Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies Bioorg.Med.Chem.Lett., 16:4163-4168, 2006 Cited by PubMed: 16765046DOI: 10.1016/j.bmcl.2006.05.092 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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