2GU8
Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 337 | 39414.0 | 1 | UniProt (P17612) Pfam (PF00069) | Homo sapiens (human) | PKA C-alpha |
| 2 | B (C) | inhibitor of CAMP-dependent protein kinase | polymer | 20 | 2226.4 | 1 | |||
| 3 | C (A) | N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE | non-polymer | 436.4 | 1 | Chemie (796) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41640.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 436.4 | |
| All* | Total formula weight | 42076.8 |
