2G7Q

Structure of the Light Chain of Botulinum Neurotoxin Serotype A Bound to Small Molecule Inhibitors

Summary for 2G7Q

• Entry DOI: 10.2210/pdb2g7q/pdb
• Related: 2G7K 2G7N 2G7P
• Descriptor: Botulinum neurotoxin type A, ZINC ION, N-HYDROXY-L-ARGININAMIDE, ... (4 entities in total)
• Functional Keywords: botulinum neurotoxin, zinc protease, snap25, hydrolase
• Biological source: Clostridium botulinum
• Cellular location: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: Q45894
• Total number of polymer chains: 2
• Total formula weight: 97737.57

Authors

Fu, Z.,Baldwin, M.R.,Boldt, G.E.,Janda, K.D.,Barbieri, J.T.,Kim, J.-J.P. (deposition date: 2006-02-28, release date: 2006-08-15, Last modification date: 2023-08-30)

• Primary citation: Fu, Z.,Chen, S.,Baldwin, M.R.,Boldt, G.E.,Crawford, A.,Janda, K.D.,Barbieri, J.T.,Kim, J.J.; Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.; Biochemistry, 45:8903-8911, 2006; PubMed: 16846233; DOI: 10.1021/bi060786z

Experimental method

X-RAY DIFFRACTION (2.41 Å)